Chithandizo chopepuka komanso hypothyroidism

Mavuto a chithokomiro ali ponseponse m'madera amakono, omwe amakhudza amuna ndi akazi ndi mibadwo yonse mosiyanasiyana.Matendawa mwina amaphonya nthawi zambiri kuposa matenda ena aliwonse ndipo chithandizo chamankhwala/mankhwala ochizira matenda a chithokomiro chakhala zaka makumi ambiri asayansi amvetsetsa za matendawa.

Funso lomwe tiyankhe m'nkhaniyi ndi lakuti - Kodi chithandizo chopepuka chingathandize kupewa komanso kuchiza matenda a chithokomiro / kuchepa kwa metabolism?
Kuyang'ana kudzera m'mabuku asayansi timawona izichithandizo chopepukaZomwe zimachitika pakugwira ntchito kwa chithokomiro zawerengedwa kangapo, mwa anthu (mwachitsanzo, Höfling DB et al., 2013), mbewa (mwachitsanzo Azevedo LH et al., 2005), akalulu (mwachitsanzo, Weber JB et al., 2014), mwa ena.Kuti timvetse chifukwa chakechithandizo chopepukamwina, kapena ayi, kukhala ndi chidwi ndi ofufuzawa, choyamba tiyenera kumvetsetsa zoyambira.

Mawu Oyamba
Hypothyroidism (chithokomiro chochepa, chithokomiro chosagwira ntchito bwino) chiyenera kuganiziridwa kuti ndizovuta kwambiri zomwe aliyense amagwerapo, osati zakuda kapena zoyera zomwe ndi okalamba okha.Palibe aliyense m'magulu amakono omwe ali ndi mahomoni abwino kwambiri a chithokomiro (Klaus Kapelari et al., 2007. Hershman JM et al., 1993. JM Corcoran et al., 1977.).Kuonjezera chisokonezo, pali zifukwa ndi zizindikiro zotsatizana ndi zovuta zina za kagayidwe kachakudya monga shuga, matenda a mtima, IBS, cholesterol yambiri, kuvutika maganizo komanso kutaya tsitsi (Betsy, 2013. Kim EY, 2015. Islam S, 2008, Dorchy H, 1985.).

Kukhala ndi 'slow metabolism' kwenikweni ndikofanana ndi hypothyroidism, ndichifukwa chake kumagwirizana ndi zovuta zina m'thupi.Amangopezeka ngati chipatala hypothyroidism ikafika potsika.

Mwachidule, hypothyroidism ndi chikhalidwe cha kuchepa kwa mphamvu mu thupi lonse chifukwa cha kuchepa kwa mahomoni a chithokomiro.Zomwe zimayambitsa zimakhala zovuta, kuphatikizapo zakudya zosiyanasiyana ndi moyo monga;kupsinjika maganizo, chibadwa, ukalamba, mafuta a polyunsaturated, kudya kwa ma carbohydrate ochepa, kudya kwa ma calorie ochepa, kugona tulo, kuledzera, komanso ngakhale kuchita masewera olimbitsa thupi mopitirira muyeso.Zinthu zina monga opaleshoni yochotsa chithokomiro, kudya kwa fluoride, mankhwala osiyanasiyana azachipatala, ndi zina zotero zimayambitsanso hypothyroidism.

Thandizo lopepuka lomwe lingakhale lothandiza kwa anthu omwe ali ndi chithokomiro chochepa?
Kuwala kofiira & infuraredi (600-1000nm)Zitha kukhala zothandiza pa metabolism m'thupi pamagulu osiyanasiyana.

1. Kafukufuku wina wasonyeza kuti kugwiritsa ntchito kuwala kofiira moyenera kungathandize kuti mahomoniwa apangidwe.(Höfling et al., 2010,2012,2013. Azevedo LH et al., 2005. Вера Александровна, 2010. Gopkalova, I. 2010.) Mofanana ndi minofu iliyonse m'thupi, chithokomiro chimafuna mphamvu kuti igwire ntchito zonse za thupi. .Popeza timadzi ta chithokomiro ndi gawo lofunikira kwambiri polimbikitsa kupanga mphamvu, mutha kuwona momwe kusowa kwake m'maselo a chithokomiro kumachepetsera kupangika kwa mahomoni a chithokomiro - njira yoyipa kwambiri.Chithokomiro chochepa -> mphamvu zochepa -> chithokomiro chochepa -> etc.

2. Thandizo lowalaikagwiritsidwa ntchito moyenerera pakhosi ikhoza kuswa chizungulire choyipachi, mwachidziwitso mwa kuwongolera kupezeka kwa mphamvu za m'deralo, motero kuonjezera kupanga mahomoni a chithokomiro ndi gland kachiwiri.Ndi chithokomiro chathanzi chobwezeretsedwa, zotsatira zabwino zambiri zotsika pansi zimachitika, pamene thupi lonse limapeza mphamvu zomwe likufunikira (Mendis-Handagama SM, 2005. Rajender S, 2011).Mahomoni a Steroid (testosterone, progesterone, etc.) kaphatikizidwe kaŵirikaŵiri - maganizo, libido ndi nyonga zimawonjezereka, kutentha kwa thupi kumawonjezeka ndipo makamaka zizindikiro zonse za kuchepa kwa kagayidwe kachakudya zimasinthidwa (Amy Warner et al., 2013) - ngakhale maonekedwe a thupi ndi thupi. kukopa kugonana kumawonjezeka.

3. Pamodzi ndi ubwino wa machitidwe okhudzana ndi chithokomiro, kugwiritsa ntchito kuwala kulikonse pa thupi kungaperekenso zotsatira za machitidwe, kudzera m'magazi (Ihsan FR, 2005. Rodrigo SM et al., 2009. Leal Junior EC et al., 2010).Ngakhale maselo ofiira a magazi alibe mitochondria;mapulateleti a magazi, maselo oyera a magazi ndi mitundu ina ya maselo omwe amapezeka m'magazi amakhala ndi mitochondria.Izi zokha zikuphunziridwa kuti muwone momwe ndi chifukwa chake zingachepetse kutupa ndi milingo ya cortisol - mahomoni opsinjika omwe amalepheretsa T4 -> T3 kuyambitsa (Albertini et al., 2007).

4. Ngati wina atapaka kuwala kofiyira kumadera ena a thupi (monga ubongo, khungu, machende, zilonda, ndi zina zotero), ofufuza ena amalingalira kuti mwina angapereke chilimbikitso chambiri.Izi zikuwonetsedwa bwino ndi maphunziro a chithandizo chopepuka pakhungu, mabala ndi matenda, pomwe m'maphunziro osiyanasiyana nthawi yamachiritso imatha kuchepetsedwa.kuwala kofiira kapena infrared(J. Ty Hopkins et al., 2004. Avci et al., 2013, Mao HS, 2012. Percival SL, 2015. da Silva JP, 2010. Gupta A, 2014. Güngörmüş M, 2009).Kuwala komweko kumawoneka kuti kungakhale kosiyana koma kogwirizana ndi momwe chithokomiro chimagwirira ntchito.

Mfundo yodziwika bwino komanso yovomerezeka yokhudzana ndi kukhudzidwa kwachindunji kwa ma light therapy imakhudza kupanga mphamvu zama cell.Zotsatira zake zimayesedwa makamaka ndi photodissociating nitric oxide (NO) kuchokera ku michere ya mitochondrial (cytochrome c oxidase, etc.).Mutha kuganiza za NO ngati mpikisano wowopsa wa okosijeni, monga momwe mpweya wa monoxide ulili.Palibe chomwe chimatseka kupanga mphamvu m'maselo, ndikupanga malo owononga kwambiri mwamphamvu, omwe kumunsi kwa mtsinje kumabweretsa cortisol / kupsinjika.Kuwala kofiyiraimapangidwa kuti iteteze poizoni wa nitric oxide, ndi kupsinjika komwe kumabweretsa, pochotsa ku mitochondria.Mwanjira imeneyi kuwala kofiyira kumatha kuganiziridwa ngati 'chitetezo chokana kupsinjika', m'malo mowonjezera nthawi yomweyo kupanga mphamvu.Zimangolola kuti mitochondria ya maselo anu igwire ntchito bwino pochepetsa kupsinjika kwa kupsinjika, m'njira yomwe mahomoni a chithokomiro okha samachita.

Chifukwa chake, ngakhale mahomoni a chithokomiro amawongolera kuchuluka kwa mitochondria ndikuchita bwino, lingaliro lozungulira chithandizo chopepuka ndikuti limatha kukulitsa ndikuwonetsetsa zotsatira za chithokomiro poletsa mamolekyu okhudzana ndi kupsinjika.Pakhoza kukhala njira zina zosalunjika zomwe chithokomiro ndi kuwala kofiyira zimachepetsa nkhawa, koma sitilowa mu izi.

Zizindikiro za kuchepa kwa metabolic rate/hypothyroidism

Kugunda kwa mtima kochepa (pansi pa 75 bpm)
Kutentha kwa thupi kochepa, kuchepera 98°F/36.7°C
Muzizizidwa nthawi zonse (makamaka manja ndi mapazi)
Khungu louma paliponse pathupi
Maganizo a Moody / okwiya
Kumva kupsinjika / nkhawa
Chifunga chaubongo, mutu
Tsitsi/zikhadabo zomakula pang'onopang'ono
Matenda a m'mimba (kudzimbidwa, crohns, IBS, SIBO, kutupa, kutentha pamtima, etc.)
Kukodza pafupipafupi
Low/no libido (ndi/kapena erections ofooka / kusapaka bwino kwa ukazi)
Kutengeka kwa yisiti/candida
Msambo wosagwirizana, wolemera, wopweteka
Kusabereka
Tsitsi locheperako/lochepa msanga.Kupatulira nsidze
Kugona koipa

Kodi chithokomiro chimagwira ntchito bwanji?
Hormone ya chithokomiro imapangidwa koyamba mu chithokomiro (chomwe chili m'khosi) makamaka T4, ndiyeno imayenda kudzera m'magazi kupita ku chiwindi ndi minyewa ina, komwe imasandulika kukhala yogwira ntchito - T3.Mahomoni a chithokomiro omwe amagwira ntchito kwambiri amatha kupita ku selo lililonse la thupi, kuchita mkati mwa maselo kuti apange mphamvu zamagetsi.Choncho chithokomiro -> chiwindi -> maselo onse.

Kodi nthawi zambiri chimalakwika ndi chiyani pakapangidwe kameneka?Pazochita za mahomoni a chithokomiro, mfundo iliyonse imatha kuyambitsa vuto:

1. Chithokomiro chokha sichikanatha kupanga mahomoni okwanira.Izi zitha kukhala chifukwa cha kusowa kwa ayodini m'zakudya, kuchuluka kwa polyunsaturated fatty acids (PUFA) kapena goitrogens m'zakudya, opaleshoni yam'mbuyomu ya chithokomiro, zomwe zimatchedwa "autoimmune" matenda a Hashimoto, ndi zina zambiri.

2. Chiwindi sichikanatha 'kuyambitsa' mahomoni (T4 -> T3), chifukwa cha kusowa kwa shuga / glycogen, kuchuluka kwa cortisol, kuwonongeka kwa chiwindi chifukwa cha kunenepa kwambiri, mowa, mankhwala osokoneza bongo ndi matenda, chitsulo chambiri, ndi zina zotero.

3. Maselo mwina sakulandira mahomoni omwe alipo.Mayamwidwe a ma cell a chithokomiro chogwira ntchito nthawi zambiri amatengera zakudya.Mafuta a polyunsaturated ochokera m'zakudya (kapena kuchokera ku mafuta osungidwa omwe amatulutsidwa panthawi ya kuwonda) amalepheretsa mahomoni a chithokomiro kulowa m'maselo.Glucose, kapena shuga wamba (fructose, sucrose, lactose, glycogen, ndi zina zotero), ndizofunikira kuti mayamwidwe a chithokomiro azitha kugwiritsidwa ntchito ndi maselo.

Hormone ya chithokomiro mu cell
Poganiza kuti palibe cholepheretsa kupanga mahomoni a chithokomiro, ndipo amatha kufikira ma cell, amachita mwachindunji komanso mosalunjika pa njira yopumira m'maselo - zomwe zimatsogolera ku okosijeni wathunthu wa shuga (mu carbon dioxide).Popanda mahomoni a chithokomiro okwanira kuti 'asungunuke' mapuloteni a mitochondrial, kupuma sikungathe kutha ndipo nthawi zambiri kumabweretsa lactic acid m'malo motulutsa mpweya woipa.

Hormoni ya chithokomiro imagwira ntchito pa mitochondria ndi phata la maselo, zomwe zimapangitsa kuti pakhale zotsatira zazifupi komanso zazitali zomwe zimapangitsa kuti kagayidwe ka okosijeni.Pakatikati, T3 imaganiziridwa kuti imakhudza mafotokozedwe a majini ena, zomwe zimatsogolera ku mitochondriogenesis, kutanthauza mitochondria yatsopano.Pa mitochondria yomwe ilipo kale, imakhala ndi mphamvu yowongoka mwachindunji kudzera pa cytochrome oxidase, komanso kupuma kosagwirizana ndi kupanga kwa ATP.

Izi zikutanthauza kuti glucose amatha kukankhidwira pansi panjira yopuma popanda kupanga ATP.Ngakhale izi zitha kuwoneka ngati zowononga, zimawonjezera kuchuluka kwa carbon dioxide yopindulitsa, ndikuyimitsa shuga kukhala lactic acid.Izi zitha kuwoneka bwino kwambiri mwa odwala matenda ashuga, omwe nthawi zambiri amakhala ndi kuchuluka kwa lactic acid komwe kumatsogolera ku lactic acidosis.Anthu ambiri a hypothyroid amapanga ngakhale lactic acid yayikulu popuma.Hormoni ya chithokomiro imathandiza mwachindunji kuchepetsa mkhalidwe wovulazawu.

Hormone ya chithokomiro imakhala ndi ntchito ina m'thupi, kuphatikiza vitamini A ndi cholesterol kupanga pregnenolone - kalambulabwalo wa mahomoni onse a steroid.Izi zikutanthauza kuti kuchepa kwa chithokomiro kumapangitsa kuti progesterone, testosterone, ndi zina zotero zikhale zochepa.Hormoni ya chithokomiro mwina ndihomoni yofunika kwambiri m'thupi, yomwe imati imayang'anira ntchito zonse zofunika komanso malingaliro aumoyo.

Chidule
Ena amati timadzi ta chithokomiro ndi 'master hormone' ya m'thupi ndipo kupanga kumadalira kwambiri chithokomiro komanso chiwindi.
Hormoni yogwira ntchito ya chithokomiro imathandizira kupanga mphamvu ya mitochondrial, kupanga mitochondria yambiri, ndi mahomoni a steroid.
Hypothyroidism ndi chikhalidwe chochepa mphamvu zama cell ndi zizindikiro zambiri.
Zomwe zimayambitsa chithokomiro chochepa zimakhala zovuta, zokhudzana ndi zakudya komanso moyo.
Zakudya zotsika zama carb komanso kuchuluka kwa PUFA m'zakudya ndizophwanya malamulo, komanso kupsinjika.

Chithokomirochithandizo chopepuka?
Popeza chithokomiro chili pansi pa khungu ndi mafuta a khosi, pafupi ndi infrared ndi mtundu wowunikira kwambiri wochizira chithokomiro.Izi ndizomveka chifukwa zimakhala zolowera kwambiri kuposa zofiira zowoneka bwino (Kolari, 1985; Kolarova et al., 1999; Enwemeka, 2003, Bjordal JM et al., 2003).Komabe, yofiira ngati yotsika kwambiri ngati 630nm yaphunziridwa kwa chithokomiro (Morcos N et al., 2015), chifukwa ndi chithokomiro chowoneka bwino.

Malangizo otsatirawa nthawi zambiri amatsatiridwa ku maphunziro:

Ma infrared LED / lasersmu 700-910nm osiyanasiyana.
100mW/cm² kapena mphamvu kachulukidwe bwino
Malangizowa amachokera pamafunde ogwira mtima m'maphunziro omwe atchulidwa pamwambapa, komanso maphunziro okhudza kulowa kwa minofu omwe atchulidwanso pamwambapa.Zina mwazinthu zomwe zimakhudza kulowa mkati ndi monga;kugunda, mphamvu, mphamvu, kukhudza minofu, polarization ndi mgwirizano.Nthawi yofunsira ikhoza kuchepetsedwa ngati zinthu zina ziwongoleredwa.

Mu mphamvu yoyenera, nyali za infrared za LED zitha kukhudza chithokomiro chonse, kutsogolo kupita kumbuyo.Kuwala kowoneka kofiira pakhosi kudzaperekanso phindu, ngakhale chipangizo champhamvu chidzafunika.Izi ndichifukwa choti zofiira zowoneka bwino sizilowa monga momwe tafotokozera kale.Monga kuyerekezera kovutirapo, ma LED ofiira a 90w + (620-700nm) ayenera kupereka zabwino.

Mitundu ina yaukadaulo wa chithandizo chopepukamonga ma lasers otsika ndi abwino, ngati mutha kuwakwanitsa.Ma laser amaphunziridwa mobwerezabwereza m'mabuku kuposa ma LED, komabe kuwala kwa LED nthawi zambiri kumawoneka ngati kofanana (Chaves ME et al., 2014. Kim WS, 2011. Min PK, 2013).

Nyali zowotcha, ma incandescent ndi ma saunas a infrared sizothandiza pakuwongolera kagayidwe kachakudya / hypothyroidism.Izi ndichifukwa cha kuchuluka kwa mitengo yamtengo wapatali, kutentha kochulukirapo / kusagwira ntchito bwino komanso kuwononga mawonekedwe.

Pansi Pansi
Kuwala kofiira kapena infraredkuchokera ku gwero la LED (600-950nm) amaphunzira chithokomiro.
Miyezo ya mahomoni a chithokomiro amawunikidwa ndikuyesedwa mu phunziro lililonse.
Matenda a chithokomiro ndi ovuta.Zakudya ndi moyo ziyeneranso kuyang'aniridwa.
Kuwala kwa LED kapena LLLT kumaphunziridwa bwino ndikuwonetsetsa chitetezo chokwanira.Ma infrared (700-950nm) ma LED amakondedwa pagawoli, zofiira zowoneka bwino ndizabwinonso.