Matenda a chithokomiro ali ponseponse m'dziko lamakono, ndipo amakhudza amuna ndi akazi onse komanso azaka zosiyanasiyana. Matendawa mwina sapezeka kawirikawiri kuposa matenda ena aliwonse ndipo chithandizo/mankhwala wamba a matenda a chithokomiro ali kumbuyo kwa zaka zambiri kuchokera pamene asayansi sanamvetsetse vutoli.
Funso lomwe tiyankhe m'nkhaniyi ndi lakuti - Kodi chithandizo cha kuwala chingathandize kupewa ndi kuchiza mavuto a chithokomiro/kagayidwe kachakudya kochepa?
Kuyang'ana m'mabuku asayansi timaona kutichithandizo cha kuwalaZotsatira za ntchito ya chithokomiro cha chithokomiro zaphunziridwa kambirimbiri, mwa anthu (monga Höfling DB et al., 2013), mbewa (monga Azevedo LH et al., 2005), akalulu (monga Weber JB et al., 2014), pakati pa ena. Kuti mumvetse chifukwa chakechithandizo cha kuwalaMwina, kapena ayi, zingakhale zosangalatsa kwa ofufuza awa, choyamba tiyenera kumvetsetsa zoyambira.
Chiyambi
Hypothyroidism (chithokomiro chochepa, chithokomiro chosagwira ntchito mokwanira) chiyenera kuonedwa ngati vuto lomwe aliyense amakumana nalo, osati vuto lakuda kapena loyera lomwe anthu okalamba okha ndi omwe amadwala nalo. Palibe aliyense m'dziko lamakono amene ali ndi mahomoni abwino kwambiri a chithokomiro (Klaus Kapelari et al., 2007. Hershman JM et al., 1993. JM Corcoran et al., 1977.). Kuwonjezera pa chisokonezochi, pali zifukwa ndi zizindikiro zofanana ndi mavuto ena ambiri monga matenda a shuga, matenda a mtima, IBS, cholesterol yambiri, kuvutika maganizo komanso kutaya tsitsi (Betsy, 2013. Kim EY, 2015. Islam S, 2008, Dorchy H, 1985.).
Kukhala ndi 'kagayidwe kachakudya pang'onopang'ono' kwenikweni ndi chinthu chimodzimodzi ndi hypothyroidism, ndichifukwa chake imagwirizana ndi mavuto ena m'thupi. Imapezeka kokha ngati hypothyroidism yachipatala ikafika pachimake.
Mwachidule, hypothyroidism ndi mkhalidwe wa kupanga mphamvu zochepa m'thupi lonse chifukwa cha kuchepa kwa ntchito ya mahomoni a chithokomiro. Zomwe zimayambitsa nthawi zambiri zimakhala zovuta, kuphatikizapo zakudya zosiyanasiyana ndi moyo monga; kupsinjika, cholowa, ukalamba, mafuta ambiri osakhuta, kudya chakudya chochepa, kudya ma calorie ochepa, kusowa tulo, kumwa mowa mwauchidakwa, komanso kuchita masewera olimbitsa thupi mopitirira muyeso. Zinthu zina monga opaleshoni yochotsa chithokomiro, kudya fluoride, mankhwala osiyanasiyana, ndi zina zotero zimayambitsanso hypothyroidism.
Chithandizo chopepuka chingathandize anthu omwe ali ndi vuto la chithokomiro chochepa?
Kuwala kofiira ndi infrared (600-1000nm)Zingakhale zothandiza pa kagayidwe kachakudya m'thupi pamlingo wosiyanasiyana.
1. Kafukufuku wina amanena kuti kugwiritsa ntchito kuwala kofiira moyenera kungathandize kuti mahomoni apangidwe bwino. (Höfling et al., 2010,2012,2013. Azevedo LH et al., 2005. Вера Александровна, 2010. Gopkalova, I. 2010.) Monga minofu ina iliyonse m'thupi, chithokomiro chimafuna mphamvu kuti chigwire ntchito zake zonse. Popeza chithokomiro chimapangidwa ndi hormone yofunika kwambiri pakulimbikitsa kupanga mphamvu, mutha kuwona momwe kusowa kwake m'maselo a chithokomiro kumachepetsera kupanga ma hormone a chithokomiro - kuzungulira koopsa kwachikale. Chithokomiro chochepa -> mphamvu yochepa -> chithokomiro chochepa -> ndi zina zotero.
2. Chithandizo chopepukaNgati atagwiritsidwa ntchito moyenera pakhosi, akhoza kusokoneza kayendedwe kake koipa, mwa lingaliro lake powonjezera mphamvu zomwe zimapezeka m'deralo, motero kuwonjezera kupanga mahomoni achilengedwe a chithokomiro ndi chithokomiro kachiwiri. Pamene chithokomiro chathanzi chabwezeretsedwa, zotsatira zabwino zambiri zimachitika, pamene thupi lonse limapeza mphamvu zomwe likufunikira (Mendis-Handagama SM, 2005. Rajender S, 2011). Kapangidwe ka mahomoni a steroid (testosterone, progesterone, ndi zina zotero) kamabwereranso - malingaliro, chilakolako cha kugonana ndi mphamvu zimawonjezeka, kutentha kwa thupi kumawonjezeka ndipo zizindikiro zonse za kagayidwe kochepa ka thupi zimasinthidwa (Amy Warner et al., 2013) - ngakhale mawonekedwe akuthupi ndi kukongola kwa kugonana kumawonjezeka.
3. Kuphatikiza pa ubwino womwe ungakhalepo chifukwa cha kukhudzana ndi chithokomiro, kugwiritsa ntchito kuwala kulikonse pa thupi kungaperekenso zotsatirapo zake, kudzera m'magazi (Ihsan FR, 2005. Rodrigo SM et al., 2009. Leal Junior EC et al., 2010). Ngakhale maselo ofiira a m'magazi alibe mitochondria; ma platelet a m'magazi, maselo oyera a m'magazi ndi mitundu ina ya maselo omwe ali m'magazi ali ndi mitochondria. Izi zokha zikuphunziridwa kuti zione momwe komanso chifukwa chake zingachepetse kutupa ndi kuchuluka kwa cortisol - hormone yovutitsa yomwe imaletsa T4 -> T3 kuyambitsa (Albertini et al., 2007).
4. Ngati munthu agwiritsa ntchito kuwala kofiira m'malo enaake a thupi (monga ubongo, khungu, machende, mabala, ndi zina zotero), ofufuza ena amaganiza kuti mwina kungapereke mphamvu yowonjezera m'deralo. Izi zawonetsedwa bwino ndi maphunziro a chithandizo cha kuwala pa matenda a pakhungu, mabala ndi matenda, komwe m'maphunziro osiyanasiyana nthawi yochira imatha kuchepetsedwa ndikuwala kofiira kapena kwa infrared(J. Ty Hopkins et al., 2004. Avci et al., 2013, Mao HS, 2012. Percival SL, 2015. da Silva JP, 2010. Gupta A, 2014. Güngörmüş M, 2009). Mphamvu ya kuwala m'deralo imawoneka ngati yosiyana koma yogwirizana ndi ntchito yachilengedwe ya mahomoni a chithokomiro.
Chiphunzitso chodziwika bwino komanso chovomerezeka cha mphamvu ya kuwala kwa kuwala chimakhudza kupanga mphamvu zamaselo. Zotsatira zake zimaganiziridwa kuti zimachitika makamaka chifukwa cha kusokoneza nitric oxide (NO) kuchokera ku ma enzymes a mitochondrial (cytochrome c oxidase, ndi zina zotero). Mungaganize kuti NO ndi mpikisano woopsa wa mpweya, monga momwe carbon monoxide ilili. NO kwenikweni imaletsa kupanga mphamvu m'maselo, ndikupanga malo owononga mphamvu kwambiri, omwe pambuyo pake amawonjezera cortisol/stress.Kuwala kofiiraimaganiziridwa kuti iteteze poizoni wa nitric oxide, komanso kupsinjika komwe kumachitika, pochotsa ku mitochondria. Mwanjira imeneyi kuwala kofiira kumatha kuonedwa ngati 'kuletsa kupsinjika', m'malo mowonjezera mphamvu nthawi yomweyo. Kumangolola mitochondria ya maselo anu kugwira ntchito bwino pochepetsa zotsatira za kupsinjika, mwanjira yomwe mahomoni a chithokomiro okha samachita.
Ngakhale kuti mahomoni a chithokomiro amathandiza kuti ma mitochondria ayambe kugwira ntchito bwino, lingaliro lokhudzana ndi chithandizo cha kuwala ndilakuti lingathandize kuti chithokomiro chizigwira ntchito bwino poletsa mamolekyu oipa okhudzana ndi kupsinjika maganizo. Pakhoza kukhala njira zina zingapo zosalunjika zomwe chithokomiro ndi kuwala kofiira zimachepetsera kupsinjika maganizo, koma sitidzazifotokoza apa.
Zizindikiro za kuchepa kwa kagayidwe kachakudya m'thupi/hypothyroidism
Kugunda kwa mtima kochepa (pansi pa 75 bpm)
Kutentha kochepa kwa thupi, kochepera 98°F/36.7°C
Kumva kuzizira nthawi zonse (makamaka manja ndi mapazi)
Khungu louma kulikonse pa thupi
Maganizo okwiya/osakhazikika
Kumva kupsinjika maganizo / nkhawa
Ubongo, mutu
Tsitsi/zikhadabo zomwe zikukula pang'onopang'ono
Mavuto am'mimba (kutsekeka m'mimba, IBS, SIBO, kudzimbidwa, kutentha pamtima, ndi zina zotero)
Kukodza pafupipafupi
Kuchepa/kusakhala ndi chilakolako chogonana (ndi/kapena kufooka kwa mamuna/kuchepa kwa mafuta m'chikazi)
Kufooka kwa yisiti/candida
Kusakhazikika kwa msambo, kolemera, kopweteka
Kusabereka
Tsitsi lochepa/lochepa mofulumira. Nsidze zopyapyala
Kugona moyipa
Kodi dongosolo la chithokomiro limagwira ntchito bwanji?
Homoni ya chithokomiro imayamba kupangidwa mu chithokomiro (chomwe chili pakhosi) makamaka ngati T4, kenako imayenda kudzera m'magazi kupita ku chiwindi ndi minofu ina, komwe imasanduka mtundu wogwira ntchito kwambiri - T3. Mtundu wogwira ntchito kwambiri wa homoni ya chithokomiro umapita ku selo iliyonse ya thupi, ikugwira ntchito mkati mwa maselo kuti ipangitse kupanga mphamvu zamaselo. Choncho chithokomiro -> chiwindi -> maselo onse.
Kodi nthawi zambiri vuto ndi chiyani pakupanga mahomoni a chithokomiro? Mu unyolo wa ntchito ya mahomoni a chithokomiro, mfundo iliyonse ingayambitse vuto:
1. Chithokomiro sichingathe kupanga mahomoni okwanira. Izi zitha kukhala chifukwa cha kusowa kwa ayodini muzakudya, kuchuluka kwa mafuta ochulukirapo (PUFA) kapena goitrogens muzakudya, opaleshoni ya chithokomiro yapitayi, matenda otchedwa 'autoimmune' a Hashimoto, ndi zina zotero.
2. Chiwindi sichingathe 'kuyambitsa' mahomoni (T4 -> T3), chifukwa cha kusowa kwa shuga/glycogen, kuchuluka kwa cortisol, kuwonongeka kwa chiwindi chifukwa cha kunenepa kwambiri, mowa, mankhwala osokoneza bongo ndi matenda, chitsulo chochuluka, ndi zina zotero.
3. Maselo sangatenge mahomoni omwe alipo. Kutenga kwa maselo mahomoni a chithokomiro nthawi zambiri kumachitika chifukwa cha zakudya. Mafuta ambiri osakhuta omwe amapezeka muzakudya (kapena mafuta osungidwa omwe amatulutsidwa panthawi yochepetsa thupi) amaletsa mahomoni a chithokomiro kulowa m'maselo. Shuga, kapena shuga wamba (fructose, sucrose, lactose, glycogen, ndi zina zotero), ndi ofunikira kuti maselo atenge komanso agwiritse ntchito mahomoni a chithokomiro.
Homoni ya chithokomiro mu selo
Poganiza kuti palibe choletsa kupanga mahomoni a chithokomiro, ndipo amatha kufikira maselo, amagwira ntchito mwachindunji komanso mwanjira ina pa njira yopumira m'maselo - zomwe zimapangitsa kuti shuga atuluke (mu carbon dioxide) yonse. Popanda mahomoni a chithokomiro okwanira 'ophatikiza' mapuloteni a mitochondrial, njira yopumira singathe ndipo nthawi zambiri imabweretsa lactic acid m'malo mwa carbon dioxide.
Homoni ya chithokomiro imagwira ntchito pa mitochondria ndi nucleus ya maselo, zomwe zimayambitsa zotsatira zazifupi komanso zazitali zomwe zimapangitsa kuti kagayidwe ka okosijeni kagayidwe kake kakhale koyenera. Mu nucleus, T3 imaganiziridwa kuti imakhudza momwe majini ena amagwirira ntchito, zomwe zimapangitsa kuti mitochondria iyambe kugwira ntchito, zomwe zikutanthauza kuti mitochondria yatsopano/yatsopano imachitika. Pa mitochondria yomwe ilipo kale, imakhala ndi mphamvu yowongolera mphamvu mwachindunji kudzera mu cytochrome oxidase, komanso imamasula mpweya wochokera ku kupanga kwa ATP.
Izi zikutanthauza kuti shuga akhoza kukankhidwira pansi pa njira yopumira popanda kufunikira kupanga ATP. Ngakhale izi zingawoneke ngati zowononga, zimawonjezera kuchuluka kwa carbon dioxide yopindulitsa, ndikuletsa shuga kusungidwa ngati lactic acid. Izi zitha kuwoneka bwino kwambiri mwa odwala matenda ashuga, omwe nthawi zambiri amakhala ndi lactic acid yambiri yomwe imabweretsa vuto lotchedwa lactic acidosis. Anthu ambiri omwe ali ndi hypothyroidism amapanga lactic acid yambiri akapuma. Homoni ya chithokomiro imagwira ntchito mwachindunji pochepetsa vutoli.
Homoni ya chithokomiro ili ndi ntchito ina m'thupi, kuphatikiza ndi vitamini A ndi cholesterol kupanga pregnenolone - yomwe imayambitsa mahomoni onse a steroid. Izi zikutanthauza kuti kuchuluka kochepa kwa chithokomiro kumapangitsa kuti progesterone, testosterone, ndi zina zotero zikhale zochepa. Kuchuluka kochepa kwa mchere wa bile kumachitikanso, zomwe zimapangitsa kuti chimbudzi chisagwire bwino ntchito. Homoni ya chithokomiro mwina ndi homoni yofunika kwambiri m'thupi, yomwe imayang'anira ntchito zonse zofunika komanso momwe munthu amamvera bwino.
Chidule
Ena amaona kuti mahomoni a chithokomiro ndi 'hormone yaikulu' ya thupi ndipo kupanga kwake kumadalira kwambiri chithokomiro ndi chiwindi.
Homoni ya chithokomiro yogwira ntchito imalimbikitsa kupanga mphamvu ya mitochondrial, kupanga ma mitochondria ambiri, ndi mahomoni a steroid.
Hypothyroidism ndi mkhalidwe wa mphamvu yochepa ya maselo yokhala ndi zizindikiro zambiri.
Zifukwa zomwe zimayambitsa kuchepa kwa chithokomiro ndi zovuta, zokhudzana ndi zakudya ndi moyo.
Zakudya zochepa zama carbohydrate ndi kuchuluka kwa PUFA mu zakudya ndizomwe zimayambitsa mavuto akulu, komanso kupsinjika maganizo.
Chithokomirochithandizo cha kuwala?
Popeza chithokomiro chili pansi pa khungu ndi mafuta a pakhosi, kuwala kwapafupi ndi infrared ndiko komwe kumaphunziridwa kwambiri pochiza chithokomiro. Izi zikumveka bwino chifukwa kumalowa kwambiri kuposa kufiira kooneka (Kolari, 1985; Kolarova et al., 1999; Enwemeka, 2003, Bjordal JM et al., 2003). Komabe, kufiira kocheperako ngati 630nm kwaphunziridwa pa chithokomiro (Morcos N et al., 2015), chifukwa ndi chithokomiro chocheperako.
Malangizo otsatirawa nthawi zambiri amatsatiridwa pa maphunziro:
Ma LED/ma laser a infraredmu 700-910nm.
100mW/cm² kapena mphamvu yabwinoko
Malangizo awa akuchokera pa mafunde ogwira mtima m'maphunziro omwe atchulidwa pamwambapa, komanso maphunziro okhudza kulowa kwa minofu omwe atchulidwanso pamwambapa. Zina mwa zinthu zina zomwe zimakhudza kulowa kwa minofu ndi monga; kugunda, mphamvu, mphamvu, kukhudzana kwa minofu, kugawanika kwa minofu ndi mgwirizano. Nthawi yogwiritsira ntchito ikhoza kuchepetsedwa ngati zinthu zina zasintha.
Mu mphamvu yoyenera, magetsi a LED a infrared angakhudze gland yonse ya chithokomiro, kuyambira kutsogolo mpaka kumbuyo. Kuwala kofiira kooneka pakhosi kudzaperekanso ubwino, ngakhale kuti padzafunika chipangizo champhamvu. Izi zili choncho chifukwa kufiira kooneka sikulowa kwambiri monga tafotokozera kale. Monga momwe taonera, ma LED ofiira a 90w+ (620-700nm) ayenera kupereka ubwino wabwino.
Mitundu ina yaukadaulo wothandiza anthu pogwiritsa ntchito kuwalaMonga ma laser otsika ndi abwino, ngati mungathe kuwagula. Ma laser amaphunziridwa mobwerezabwereza m'mabuku kuposa ma LED, komabe kuwala kwa LED nthawi zambiri kumaonedwa kuti ndi kofanana (Chaves ME et al., 2014. Kim WS, 2011. Min PK, 2013).
Nyali zotenthetsera, ma incandescent ndi ma sauna a infrared sizothandiza kwambiri pakukweza kagayidwe kachakudya m'thupi / hypothyroidism. Izi zimachitika chifukwa cha ngodya yopingasa, kutentha kwambiri / kusagwira ntchito bwino komanso kuwononga mphamvu zamagetsi.
Mfundo Yofunika Kwambiri
Kuwala kofiira kapena kwa infraredKuchokera ku gwero la LED (600-950nm) amaphunziridwa za chithokomiro.
Mulingo wa mahomoni a chithokomiro umawonedwa ndikuyesedwa mu kafukufuku aliyense.
Thupi la chithokomiro ndi lovuta. Zakudya ndi moyo ziyeneranso kuganiziridwa.
Chithandizo cha kuwala kwa LED kapena LLLT chaphunziridwa bwino ndipo chimatsimikizira chitetezo chokwanira. Ma LED a infrared (700-950nm) ndi omwe amakondedwa kwambiri m'munda uno, kufiira kowoneka bwino nakonso kuli bwino.