Matenda a Alzheimer's, matenda obwera chifukwa cha kulephera kwa mitsempha, amaonekera kudzera mu zizindikiro monga kuiwalaiwala, aphasia, agnosia, ndi kulephera kugwira ntchito bwino kwa thupi. Mwachikhalidwe, odwala akhala akugwiritsa ntchito mankhwala kuti achepetse zizindikiro. Komabe, chifukwa cha zofooka ndi zotsatirapo zoyipa za mankhwalawa, ofufuza atembenukira ku chithandizo cha phototherapy chosavulaza, zomwe zapangitsa kuti zinthu zipite patsogolo kwambiri m'zaka zaposachedwa.
Posachedwapa, gulu lotsogozedwa ndi Pulofesa Zhou Feifan wochokera ku Biomedical Engineering College of Hainan University linapeza kuti chithandizo cha transcranial phototherapy chosakhudzana ndi kukhudza ubongo chingachepetse zizindikiro za matenda ndikuwonjezera luso la kuzindikira mwa mbewa zokalamba komanso zomwe zili ndi matenda a Alzheimer's. Kupeza kumeneku, komwe kunafalitsidwa mu magazini ya Nature Communications, kumapereka njira yabwino yothanirana ndi matenda a neurodegenerative.
Kumvetsetsa Matenda a Alzheimer's
Chifukwa chenicheni cha matenda a Alzheimer sichikudziwika bwino, koma chimadziwika ndi kusakanikirana kwa mapuloteni a beta-amyloid komanso kusokonekera kwa mitsempha yamagazi, zomwe zimapangitsa kuti mitsempha isagwire bwino ntchito komanso kuti ubongo usamagwire bwino ntchito. Ubongo, monga chiwalo chomwe chimagwira ntchito kwambiri m'thupi, umatulutsa zinyalala zambiri za metabolic panthawi ya ntchito ya mitsempha. Kuchuluka kwa zinyalalazi kumatha kuwononga ma neuron, zomwe zimapangitsa kuti zichotsedwe bwino kudzera mu lymphatic system.
Mitsempha ya meningeal lymphatic, yofunika kwambiri pa kutulutsa madzi m'mitsempha yapakati, imagwira ntchito yofunika kwambiri pochotsa mapuloteni oopsa a beta-amyloid, zinyalala za kagayidwe kachakudya, komanso kuwongolera chitetezo chamthupi, zomwe zimapangitsa kuti zikhale chandamale chochizira.
Zotsatira za Phototherapy pa Alzheimer's
Gulu la Pulofesa Zhou linagwiritsa ntchito laser ya 808 nm pafupi ndi infrared kwa milungu inayi ya chithandizo cha transcranial chosakhudzana ndi kukhudza mbewa zokalamba ndi Alzheimer's. Chithandizochi chinathandiza kwambiri ntchito ya maselo a meningeal lymphatic endothelial, chinathandiza kuti madzi a m'magazi asinthe, ndipo pamapeto pake chinachepetsa zizindikiro za matenda komanso kusintha kwa magwiridwe antchito a ubongo m'mbewa.
Kulimbikitsa Ntchito ya Mitsempha kudzera mu Phototherapy
Phtotherapy ikhoza kukulitsa ndikuwongolera ntchito ya mitsempha kudzera mu njira zosiyanasiyana. Mwachitsanzo, njira yodzitetezera ku matenda a Alzheimer's imagwira ntchito yofunika kwambiri pa matenda a Alzheimer's. Kafukufuku waposachedwapa akusonyeza kuti kuwala kwa laser kobiriwira kwa 532 nm kumatha kulimbikitsa ntchito ya maselo a chitetezo chamthupi, kuyambitsa njira zamkati mwa mitsempha yakuya yapakati, kukonza matenda a dementia ya mitsempha yamagazi, ndikuwonjezera mphamvu ya kuyenda kwa magazi ndi zizindikiro zachipatala mwa odwala a Alzheimer's. Kuwala kwa mitsempha yamagazi koyambirira kwa laser kobiriwira kwawonetsa kusintha kwakukulu mu kukhuthala kwa magazi, kukhuthala kwa plasma, kusonkhana kwa maselo ofiira amagazi, ndi mayeso a neuropsychological.
Chithandizo cha kuwala kofiira ndi infrared (photobiomodulation) chomwe chimagwiritsidwa ntchito m'madera am'mbali mwa thupi (kumbuyo ndi miyendo) chingayambitse chitetezo chamthupi kapena njira zodzitetezera zamkati mwa maselo oyambira, zomwe zimathandiza kuti mitsempha yamagazi ipulumuke komanso kuti majini azitha kuonekera bwino.
Kuwonongeka kwa okosijeni ndi njira yofunika kwambiri yochizira matenda a Alzheimer's. Kafukufuku akusonyeza kuti kuwala kofiira kumatha kuwonjezera ntchito ya ATP ya maselo, kuyambitsa kusintha kwa kagayidwe kachakudya kuchokera ku glycolysis kupita ku ntchito ya mitochondrial mu microglia yotupa yomwe imakhudzidwa ndi oligomeric beta-amyloid, kukulitsa milingo ya microglia yotsutsana ndi kutupa, kuchepetsa ma cytokines oyambitsa kutupa, ndikuyambitsa phagocytosis kuti apewe kufa kwa mitsempha.
Kuwongolera kukhala maso, kuzindikira, ndi chisamaliro chokhazikika ndi njira ina yabwino yowonjezerera moyo wa odwala a Alzheimer. Ofufuza apeza kuti kuwunikira kuwala kwa buluu kwaufupi kumakhudza bwino ntchito ya kuzindikira ndi kuwongolera malingaliro. Kuwala kwa kuwala kwa buluu kumatha kulimbikitsa ntchito ya mitsempha, kusintha ntchito ya acetylcholinesterase (AchE) ndi choline acetyltransferase (ChAT), motero kumawongolera luso lophunzira ndi kukumbukira.
Zotsatira Zabwino za Phototherapy pa Ubongo wa Neurons
Kafukufuku wodziwika bwino akutsimikizira zotsatira zabwino za phototherapy pa ntchito ya mitsempha ya muubongo. Zimathandiza kuyambitsa njira zodzitetezera zamkati mwa maselo a chitetezo chamthupi, kulimbikitsa kufalikira kwa majini a neuronal, komanso kulimbitsa kuchuluka kwa mpweya wochitapo kanthu m'mitochondrial. Zomwe zapezekazi zimakhazikitsa maziko olimba a ntchito zachipatala za phototherapy.
Kutengera ndi malingaliro awa, MERICAN Optical Energy Research Center, mogwirizana ndi gulu la ku Germany ndi mayunivesite angapo, ofufuza, ndi mabungwe azachipatala, adachita kafukufuku wokhudza anthu azaka zapakati pa 30-70 omwe ali ndi vuto lochepa la kuzindikira, kukumbukira zinthu molakwika, kusamvetsetsa bwino komanso kusaganiza bwino, komanso kuchepa kwa luso lophunzira. Ophunzirawo adatsatira malangizo azakudya komanso moyo wathanzi pamene anali kulandira chithandizo cha phototherapy m'chipinda chaumoyo cha MERICAN, ndi mitundu yosiyanasiyana ya mankhwala ndi mlingo.
Pambuyo pa miyezi itatu ya mayeso a ubongo, mayeso a maganizo, ndi mayeso a ubongo, zotsatira zake zinawonetsa kusintha kwakukulu mu zigoli za MMSE, ADL, ndi HDS pakati pa ogwiritsa ntchito phototherapy ya m'chipinda chaumoyo. Ophunzirawo adawonanso chidwi chowoneka bwino, kugona bwino, komanso nkhawa zochepa.
Zomwe zapezekazi zikusonyeza kuti chithandizo cha phototherapy chingathandize kuwongolera ntchito ya maselo a muubongo, kuchepetsa kutupa kwa mitsempha ndi matenda ena okhudzana ndi izi, kukonza luso la kuzindikira, komanso kuwonjezera kukumbukira. Kuphatikiza apo, chimatsegula njira zatsopano zochiritsira phototherapy kuti chikhale njira yopewera matenda.
