Matenda a Alzheimer's, omwe amayamba chifukwa cha matenda a neurodegenerative, amawonekera kudzera muzizindikiro monga kukumbukira kukumbukira, aphasia, agnosia, ndi kulephera kwa magwiridwe antchito. Mwachizoloŵezi, odwala akhala akudalira mankhwala kuti athetse zizindikiro. Komabe, chifukwa cha zofooka ndi zotsatira zomwe zingakhalepo za mankhwalawa, ochita kafukufuku ayang'ana chidwi chawo ku phototherapy yosasokoneza, ndikupindula kwambiri m'zaka zaposachedwa.
Posachedwapa, gulu lotsogozedwa ndi Pulofesa Zhou Feifan wa ku Biomedical Engineering College ku Hainan University adapeza kuti osalumikizana ndi transcranial phototherapy amatha kuchepetsa zizindikiro za matenda ndikukulitsa luso la kuzindikira kwa mbewa okalamba komanso omwe ali ndi Alzheimer's. Zomwe zapezazi, zosindikizidwa mu nyuzipepala ya Nature Communications, zimapereka njira yodalirika yothanirana ndi matenda a neurodegenerative.
Kumvetsetsa Matenda a Alzheimer's Pathology
Zomwe zimayambitsa matenda a Alzheimer's sizikudziwikabe, koma zimadziwika ndi kuphatikizika kwa mapuloteni a beta-amyloid ndi ma neurofibrillary tangles, zomwe zimayambitsa kusokonezeka kwa neuronal komanso kuchepa kwa chidziwitso. Ubongo, monga chiwalo chogwira ntchito kwambiri m'thupi, umatulutsa zinyalala za metabolic panthawi ya ubongo. Kuchulukirachulukira kwa zinyalalazi kumatha kuwononga ma neuron, zomwe zimafunikira kuchotsedwa koyenera kudzera m'mitsempha yamagazi.
Mitsempha ya meningeal lymphatic, yofunika kwambiri pakutulutsa kwapakati pamanjenje, imagwira ntchito yofunika kwambiri pakuchotsa mapuloteni oopsa a beta-amyloid, zinyalala za metabolic, ndikuwongolera chitetezo chamthupi, kuwapangitsa kukhala chandamale cha chithandizo.
Phototherapy's Impact pa Alzheimer's
Gulu la Professor Zhou linagwiritsa ntchito laser ya 808 nm pafupi ndi infrared kwa milungu inayi ya transcranial phototherapy pa okalamba ndi mbewa za Alzheimer's. Kuchiza kumeneku kumathandizira kwambiri kugwira ntchito kwa ma cell a meningeal lymphatic endothelial, kupititsa patsogolo madzi a m'mitsempha, ndipo pamapeto pake kumachepetsa zizindikiro za matenda komanso kupititsa patsogolo chidziwitso cha mbewa.
Kupititsa patsogolo Ntchito ya Neuronal kudzera mu Phototherapy
Phtotherapy imatha kupititsa patsogolo ntchito za neuronal kudzera munjira zosiyanasiyana. Mwachitsanzo, chitetezo cha mthupi chimagwira ntchito yofunika kwambiri pa matenda a Alzheimer's. Kafukufuku waposachedwa akuwonetsa kuti kuwala kwa laser 532 nm green laser kumatha kulimbikitsa magwiridwe antchito a chitetezo chamthupi, kuyambitsa njira zama neuroni zapakati, kupititsa patsogolo kusokonezeka kwa mitsempha yamagazi, komanso kupititsa patsogolo kayendedwe ka magazi ndi zizindikiro zachipatala mwa odwala a Alzheimer's. Kuwala koyambirira kwa laser vascular radiation kwawonetsa kusintha kwakukulu kwa kukhuthala kwa magazi, kukhuthala kwa plasma, kuphatikizika kwa maselo ofiira a magazi, komanso kuyesa kwa neuropsychological.
Thandizo lofiira ndi la infrared (photobiomodulation) lomwe limagwiritsidwa ntchito kumalo ozungulira thupi (kumbuyo ndi miyendo) limatha kuyambitsa ma cell a chitetezo chamthupi kapena njira zodzitetezera zamkati, zomwe zimathandizira kupulumuka kwa neuronal komanso mawonekedwe opindulitsa a jini.
Kuwonongeka kwa okosijeni ndi njira yovuta kwambiri pakukula kwa Alzheimer's. Kafukufuku akuwonetsa kuti kuwala kofiyira kumatha kukulitsa ntchito zama cell a ATP, kupangitsa kusintha kwa metabolic kuchoka ku glycolysis kupita ku mitochondrial mu kutupa kwa microglia yomwe imakhudzidwa ndi oligomeric beta-amyloid, kukulitsa milingo ya anti-inflammatory microglia, kuchepetsa ma cytokines oyambitsa kutupa, ndikuyambitsa phagocytosis kuteteza neuronal. imfa.
Kupititsa patsogolo kukhala tcheru, kuzindikira, ndi chisamaliro chokhazikika ndi njira ina yabwino yopititsira patsogolo moyo wa odwala a Alzheimer's. Ofufuza apeza kuti kuyatsa kwa buluu kwakanthawi kochepa kumakhudza magwiridwe antchito amalingaliro komanso kuwongolera malingaliro. Kuwala kowala kwa buluu kumatha kulimbikitsa zochitika za neural circuit, kukhudza ntchito ya acetylcholinesterase (AchE) ndi choline acetyltransferase (Chat), potero kupititsa patsogolo luso la kuphunzira ndi kukumbukira.
Zotsatira Zabwino za Phototherapy pa Mitsempha Yaubongo
Kafukufuku wodalirika yemwe akuchulukirachulukira amatsimikizira zotsatira zabwino za phototherapy pakugwira ntchito kwa ma neuron muubongo. Zimathandizira kuyambitsa njira zodzitetezera zamkati mwa maselo a chitetezo chamthupi, zimathandizira kupulumuka kwa jini, ndikuwongolera mitochondrial reactive oxygen mitundu. Zotsatirazi zimakhazikitsa maziko olimba a ntchito zachipatala za phototherapy.
Kutengera izi, MERICAN Optical Energy Research Center, mogwirizana ndi gulu la Germany ndi mayunivesite angapo, kafukufuku, ndi mabungwe azachipatala, adachita kafukufuku wokhudza anthu azaka zapakati pa 30-70 omwe ali ndi vuto lochepa lachidziwitso, kuchepa kwa kukumbukira, kuchepa kwa kuzindikira ndi kuweruza, ndi kuchepa kwa luso la kuphunzira. Omwe adatenga nawo mbali adatsatira malangizo azakudya komanso moyo wathanzi pomwe amalandila chithandizo chamankhwala muchipinda chachipatala cha MERICAN, chokhala ndi mitundu yofananira yamankhwala ndi mlingo wake.
Pambuyo pa miyezi itatu ya mayesero a neuropsychological, mayeso a maganizo, ndi kufufuza kwachidziwitso, zotsatira zake zinawonetsa kusintha kwakukulu kwa MMSE, ADL, ndi HDS zambiri pakati pa ogwiritsa ntchito phototherapy cabin phototherapy. Otenga nawo mbali adawonanso chidwi chowoneka bwino, kugona bwino, komanso kuchepetsa nkhawa.
Zomwe anapezazi zikusonyeza kuti phototherapy ikhoza kukhala chithandizo chothandizira kuwongolera zochitika za ubongo, kuchepetsa kutukusira kwa neuroinflammation ndi ma pathologies ena, kupititsa patsogolo kuzindikira, ndi kukumbukira. Kuphatikiza apo, imatsegula njira zatsopano za phototherapy kuti zisinthe kukhala njira yodzitetezera.
