Rosacea ndi vuto lomwe limadziwika ndi kufiira kumaso ndi kutupa.Zimakhudza pafupifupi 5% ya anthu padziko lonse lapansi, ndipo ngakhale zomwe zimayambitsa zimadziwika, sizidziwika kwambiri.Amaonedwa kuti ndi khungu la nthawi yayitali, ndipo nthawi zambiri amakhudza akazi a ku Ulaya / Caucasus omwe ali ndi zaka zoposa 30. Pali mitundu yosiyanasiyana ya rosacea ndipo imatha kukhudza aliyense.
Thandizo la kuwala kofiyira limaphunziridwa bwino pazinthu monga machiritso a khungu, kutupa kwathunthu, collagen pakhungu, ndi zina zokhudzana ndi khungu monga ziphuphu zakumaso.Mwachibadwa chidwi chakula pakugwiritsa ntchito kuwala kofiira kwa rosacea.M'nkhaniyi tiwona ngati chithandizo cha kuwala kofiira (chomwe chimatchedwanso photobiomodulation, LED therapy, laser therapy, cold laser, light therapy, LLLT, etc.) chingathandize kuchiza rosacea.
Mitundu ya Rosacea
Aliyense amene ali ndi rosacea ali ndi zizindikiro zosiyana komanso zapadera.Ngakhale rosacea nthawi zambiri imagwirizanitsidwa ndi kufiira kwa nkhope kuzungulira mphuno ndi masaya, pali zizindikiro zina zomwe zingathe kusweka ndikugawidwa mu rosacea 'subtypes':
Subtype 1, yomwe imatchedwa 'Erythematotelangiectatic Rosacea' (ETR), ndi rosacea yomwe imawoneka yofiira kumaso, kutupa pakhungu, mitsempha yamagazi pafupi ndi pamwamba komanso nthawi yotuluka.Erythema amachokera ku mawu achi Greek erythros, omwe amatanthauza wofiira - ndipo amatanthauza khungu lofiira.
Subtype 2, Acne rosacea (dzina la sayansi - papulopustular), ndi rosacea pomwe khungu lofiira limaphatikizidwa ndi kuphulika kosalekeza kapena kwapakatikati ngati ziphuphu zakumaso (ma pustules ndi papules, osati mitu yakuda).Mtundu uwu ukhoza kuyambitsa kutentha kapena kuluma.
Subtype 3, AKA phymatous rosacea kapena rhinophyma, ndi mtundu wosowa kwambiri wa rosacea ndipo umakhudza mbali zina za nkhope kumakulirakulira - makamaka mphuno (mphuno ya mbatata).Imafala kwambiri mwa amuna achikulire ndipo imayamba ngati mtundu wina wa rosacea.
Subtype 4 ndi rosacea ya diso, kapena ocular rosacea, ndipo imakhudza maso owombera magazi, maso amadzimadzi, kumverera kwa chinachake m'diso, kuyaka, kuyabwa ndi kutumphuka.
Kudziwa za subtypes za rosacea ndikofunikira kuti mudziwe ngati muli nazo.Ngati palibe chomwe chachitidwa kuti athane ndi rosacea, zimayamba kuipiraipira pakapita nthawi.Mwamwayi, kugwiritsa ntchito kuwala kofiira pochiza rosacea sikumasintha ndi subtype.Kutanthawuza kuti njira yofanana ya red light therapy protocol ingagwire ntchito kwa ma subtypes onse.Chifukwa chiyani?Tiyeni tiwone zomwe zimayambitsa rosacea.
Choyambitsa chenicheni cha Rosacea
(...ndi chifukwa chiyani chithandizo chopepuka chingathandize)
Zaka makumi angapo zapitazo, rosacea poyamba ankakhulupirira kuti ndi zotsatira za matenda a bakiteriya.Pamene maantibayotiki (kuphatikiza tetracycline) adagwira ntchito pang'onopang'ono kuthana ndi zizindikiro, zidawoneka ngati lingaliro labwino….koma mwachangu zidadziwika kuti palibe mabakiteriya omwe amakhudzidwa.
Madokotala ambiri ndi akatswiri a rosacea masiku ano adzakuuzani kuti rosacea ndi yodabwitsa ndipo palibe amene wapeza chifukwa chake.Ena adzalozera ku nthata za Demodex monga zomwe zimayambitsa, koma pafupifupi aliyense ali ndi izi ndipo si onse omwe ali ndi rosacea.
Kenako amalemba 'zoyambitsa' zosiyanasiyana m'malo mwa zomwe zimayambitsa, kapena kupanga malingaliro oti majini osadziwika komanso zinthu zachilengedwe ndizomwe zimayambitsa.Ngakhale kuti majini kapena epigenetic zinthu zimatha kupangitsa kuti munthu atenge rosacea (chibale ndi munthu wina), samazindikira - sizomwe zimayambitsa.
Zinthu zosiyanasiyana zimachititsa kuti zizindikiro za rosacea zikhale zovuta kwambiri (caffeine, zonunkhira, zakudya zina, nyengo yozizira / yotentha, kupsinjika maganizo, mowa, etc.), koma izonso sizimayambitsa.
Ndiye ndi chiyani?
Zizindikiro za chifukwa
Chizindikiro choyamba cha chifukwa chake ndi chakuti rosacea nthawi zambiri imayamba pambuyo pa zaka 30. Iyi ndi nthawi yomwe zizindikiro zoyamba za ukalamba zimawonekera.Anthu ambiri amawona imvi yawo yoyamba ndipo khungu loyamba laling'ono limakwinya kuzungulira m'badwo uno.
Chidziwitso china ndi chakuti maantibayotiki amathandiza kuthana ndi zizindikiro - ngakhale palibe matenda enieni (chidziwitso: maantibayotiki amatha kukhala ndi zotsatira zanthawi yochepa).
Kuthamanga kwa magazi pakhungu lomwe lakhudzidwa ndi rosacea ndi 3 mpaka 4 kuposa khungu labwinobwino.Izi hyperemia zotsatira zimachitika pamene minofu ndi maselo sangathe kuchotsa mpweya m'magazi.
Tikudziwa kuti rosacea si nkhani yodzikongoletsa chabe, koma imakhudza kusintha kwakukulu kwa kukula kwa fibrotic pakhungu (motero mphuno ya mbatata mu subtype 3) ndi kukula kwa mitsempha yamagazi (chifukwa chake mitsempha / kuphulika).Zizindikiro zomwezi zikachitika kwinakwake m'thupi (mwachitsanzo, uterine fibroids) zimafunika kufufuza kofunikira, koma pakhungu zimawonedwa ngati zodzikongoletsera zomwe ziyenera 'kuyendetsedwa' mwa 'kupewa zoyambitsa', ndipo pambuyo pake ngakhale maopaleshoni ochotsa khungu lokhuthala. .
Rosacea ndi vuto lalikulu chifukwa choyambitsa chake ndi momwe thupi limayendera mkati mwa thupi.Kusinthika kwapakhungu sikumangokhudza khungu - kumakhudzanso thupi lonse lamkati.
Kuthamanga, mitsempha yamagazi yomwe ikukula / yowonongeka ndi kukhuthala kwa khungu kumatha kuwonedwa mosavuta mu rosacea, chifukwa ikuwonekera pakhungu - pamwamba pa thupi.Mwanjira ina, ndi dalitso kupeza zizindikiro za rosacea, chifukwa zimakuwonetsani kuti pali chinachake cholakwika mkati.Kuthothoka kwa tsitsi la amuna ndi chinthu chofanana chifukwa kumasonyeza kusokonezeka kwa mahomoni.
Zowonongeka za Mitochondrial
Kuwona ndi kuyeza konse kokhudzana ndi rosacea kumatsimikizira zovuta za mitochondrial monga gwero la rosacea.
Mitochondria sangathe kugwiritsa ntchito mpweya bwino pamene awonongeka.Kulephera kugwiritsa ntchito mpweya kumawonjezera kuthamanga kwa magazi kupita ku minofu.
Mitochondria imapanga lactic acid pamene sangathe kupeza ndi kugwiritsa ntchito mpweya, zomwe zimatsogolera ku vasodilation mwamsanga ndi kukula kwa fibroblasts.Ngati vutoli litalikitsa pakapita nthawi, mitsempha yatsopano yamagazi imayamba kukula.
Zinthu zosiyanasiyana za mahomoni ndi zachilengedwe zimatha kupangitsa kuti mitochondrial isagwire bwino ntchito, koma pankhani ya chithandizo cha kuwala kofiyira, chofunikira kwambiri chimachokera ku molekyulu yotchedwa Nitric Oxide.
Red Light Therapy ndi Rosacea
Lingaliro lalikulu lofotokozera zotsatira za chithandizo cha kuwala kwachokera pa molekyulu yotchedwa Nitric Oxide (NO).
Ichi ndi molekyulu yomwe ingakhale ndi zotsatira zosiyanasiyana pa thupi, monga kulepheretsa kupanga mphamvu, vasodilation / kukulitsa mitsempha ya magazi, ndi zina zotero.Chomwe timasangalatsidwa nacho kwambiri pazamankhwala opepuka ndikuti NO amamanga pamalo ofunikira pamayendedwe anu amagetsi a mitochondrial, kuyimitsa kuyenda kwamphamvu.
Imatsekereza magawo omaliza a kupuma, motero imakulepheretsani kupeza mphamvu yayikulu (ATP) ndi mpweya woipa uliwonse kuchokera ku glucose/oxygen.Chifukwa chake anthu akakhala ndi chiwopsezo chochepa cha kagayidwe kachakudya akamakalamba kapena kukhala ndi nkhawa / njala, NO iyi nthawi zambiri imakhala ndi udindo.Ndizomveka mukamaganizira za izi, mwachilengedwe kapena pakupulumuka, mumafunika njira yochepetsera kagayidwe kanu kagayidwe kazakudya nthawi zocheperako chakudya / calorie.Sizikupanga nzeru kwambiri mu dziko lamakono kumene NO milingo akhoza kutengera yeniyeni mitundu ya amino zidulo mu zakudya, kuipitsidwa kwa mpweya, nkhungu, zinthu zina zakudya, yokumba kuwala, etc. Kupanda mpweya woipa mu thupi lathu komanso. amachepetsa kutupa.
Thandizo lowala limawonjezera kupanga mphamvu zonse (ATP) ndi carbon dioxide (CO2).CO2 nayonso imalepheretsa ma cytokines osiyanasiyana oyambitsa kutupa ndi ma prostaglandins.Choncho chithandizo chopepuka chimachepetsa kuchuluka kwa kutupa m'thupi / dera.
Kwa rosacea chofunikira kwambiri ndikuti chithandizo chopepuka chichepetsa kutupa ndi kufiira m'derali, komanso kuthetsa vuto la kuchepa kwa okosijeni (zomwe zidapangitsa kuti mitsempha yamagazi ikule komanso kukula kwa fibroblast).
Chidule
Pali ma subtypes osiyanasiyana ndi mawonetseredwe a rosacea
Rosacea ndi chizindikiro cha ukalamba, monga makwinya ndi imvi
Choyambitsa cha rosacea ndi kuchepa kwa mitochondrial m'maselo
Thandizo lofiira lofiira limabwezeretsa mitochondria ndikuchepetsa kutupa, kuteteza rosacea
Nthawi yotumiza: Sep-30-2022