Rosacea ndi matenda omwe nthawi zambiri amadziwika ndi kufiira kwa nkhope ndi kutupa. Amakhudza pafupifupi 5% ya anthu padziko lonse lapansi, ndipo ngakhale kuti zomwe zimayambitsa matendawa ndizodziwika, sizidziwika bwino. Amaonedwa kuti ndi matenda akhungu kwa nthawi yayitali, ndipo nthawi zambiri amakhudza akazi aku Europe/Caucasus opitirira zaka 30. Pali mitundu yosiyanasiyana ya rosacea ndipo ingakhudze aliyense.
Chithandizo cha kuwala kofiira chimaphunziridwa bwino pazinthu monga kuchiritsa khungu, kutupa konsekonse, collagen pakhungu, ndi matenda osiyanasiyana okhudzana ndi khungu monga ziphuphu.Mwachibadwa chidwi cha anthu chawonjezeka pakugwiritsa ntchito kuwala kofiira pa rosacea. M'nkhaniyi tiona ngati chithandizo cha kuwala kofiira (chomwe chimadziwikanso kuti photobiomodulation, LED therapy, laser therapy, cold laser, light therapy, LLLT, ndi zina zotero) chingathandize kuchiza rosacea.
Mitundu ya Rosacea
Aliyense amene ali ndi rosacea ali ndi zizindikiro zosiyana pang'ono komanso zapadera. Ngakhale kuti rosacea nthawi zambiri imagwirizanitsidwa ndi kufiira kwa nkhope kuzungulira mphuno ndi masaya, pali zizindikiro zina zomwe zingagawidwe m'magulu a rosacea 'subtypes':
Mtundu woyamba, wotchedwa 'Erythematotelangiectatic Rosacea' (ETR), ndi mtundu wa rosacea womwe umawonekera ndi kufiira kwa nkhope, kutupa kwa khungu, mitsempha yamagazi pafupi ndi pamwamba komanso nthawi yotuluka magazi. Erythema imachokera ku liwu lachi Greek erythros, lomwe limatanthauza kufiira - ndipo limatanthauza khungu lofiira.
Subtype 2, Acne rosacea (dzina la sayansi - papulopustular), ndi rosacea komwe khungu lofiira limaphatikizidwa ndi ziphuphu zosalekeza kapena zosakhalitsa (ma pustules ndi ma papules, osati mitu yakuda). Mtundu uwu ungayambitse kutentha kapena kupweteka.
Subtype 3, yomwe imatchedwanso phymatous rosacea kapena rhinophyma, ndi mtundu wosowa wa rosacea ndipo umakhudza ziwalo za nkhope kukhala zokhuthala komanso zazikulu - nthawi zambiri mphuno (mphuno ya mbatata). Imapezeka kwambiri mwa amuna achikulire ndipo nthawi zambiri imayamba ngati mtundu wina wa rosacea.
Mtundu wachinayi ndi rosacea ya diso, kapena rosacea ya maso, ndipo imakhudza maso ofiira, maso otuluka madzi, kumva chinachake m'diso, kutentha, kuyabwa ndi kutumphuka.
Kudziwa za mitundu yosiyanasiyana ya rosacea ndikofunikira podziwa ngati muli nayodi. Ngati palibe chomwe chachitika kuti muthane ndi rosacea, nthawi zambiri imaipiraipira pakapita nthawi. Mwamwayi, kugwiritsa ntchito kwa chithandizo cha kuwala kofiira pochiza rosacea sikusintha ndi mtundu wamtunduwu. Kutanthauza kuti njira yomweyo yothandizira kuwala kofiira ingagwire ntchito pa mitundu yonse yamtunduwu. Chifukwa chiyani? Tiyeni tiwone zomwe zimayambitsa rosacea.
Chifukwa chenicheni cha rosacea
(...ndi chifukwa chake chithandizo cha kuwala chingathandize)
Zaka makumi angapo zapitazo, rosacea poyamba inkaganiziridwa kuti imachokera ku matenda a bakiteriya. Popeza maantibayotiki (kuphatikizapo tetracycline) ankagwira ntchito bwino pochiza zizindikiro, zinkaoneka ngati chiphunzitso chabwino….koma mwamsanga zinapezeka kuti palibe mabakiteriya omwe akukhudzidwa.
Madokotala ambiri ndi akatswiri pa rosacea masiku ano angakuuzeni kuti rosacea ndi yovuta kumvetsa ndipo palibe amene wapeza chomwe chimayambitsa. Ena anganene kuti nthata za Demodex ndiye zimayambitsa, koma pafupifupi aliyense ali ndi izi ndipo si aliyense amene ali ndi rosacea.
Kenako adzalemba 'zimayambitsa' zosiyanasiyana m'malo mwa chomwe chimayambitsa, kapena kupereka malingaliro akuti majini osatchulidwa ndi zinthu zachilengedwe ndi zomwe zimayambitsa. Ngakhale kuti zinthu za majini kapena epigenetic zimatha kupangitsa munthu kudwala rosacea (poyerekeza ndi munthu wina), sizimatsimikiza - sizomwe zimayambitsa.
Zinthu zosiyanasiyana zimathandiza kwambiri kuopsa kwa zizindikiro za rosacea (caffeine, zonunkhira, zakudya zina, nyengo yozizira/yotentha, nkhawa, mowa, ndi zina zotero), koma sizilinso zomwe zimayambitsa.
Ndiye ndi chiyani?
Zizindikiro za chifukwa
Chizindikiro choyamba cha chomwe chimayambitsa matendawa ndi chakuti rosacea nthawi zambiri imayamba munthu akakwanitsa zaka 30. Iyi ndi nthawi yomwe zizindikiro zoyamba za ukalamba zimaonekera. Anthu ambiri amaona tsitsi lawo loyamba la imvi ndi makwinya ang'onoang'ono pakhungu lawo pafupifupi msinkhu uno.
Chidziwitso china ndi chakuti maantibayotiki amathandiza kuthana ndi zizindikiro - ngakhale palibe matenda enieni (chidziwitso: maantibayotiki amatha kukhala ndi zotsatira zotsutsana ndi kutupa kwakanthawi kochepa).
Kuyenda kwa magazi kupita ku khungu lomwe lakhudzidwa ndi rosacea kumakhala kokwera nthawi 3 mpaka 4 kuposa kwa khungu labwinobwino. Kuchuluka kwa magazi kumeneku kumachitika pamene minofu ndi maselo sangathe kutulutsa mpweya m'magazi.
Tikudziwa kuti rosacea si vuto lokongoletsa kokha, koma limakhudza kusintha kwakukulu kwa kukula kwa fibrotic pakhungu (motero mphuno ya mbatata mu subtype 3) ndi kukula kwa mitsempha yamagazi yolowerera (motero mitsempha/kutuluka kwa madzi). Zizindikiro zomwezi zikachitika kwina m'thupi (monga uterine fibroids) zimafunika kufufuzidwa kwambiri, koma pakhungu zimaonedwa ngati mavuto okongoletsa omwe 'ayenera kuthetsedwa' mwa 'kupewa zoyambitsa', ndipo pambuyo pake ngakhale opaleshoni yochotsa khungu lokhuthala.
Rosacea ndi vuto lalikulu chifukwa chomwe chimayambitsa matendawa ndi momwe thupi limagwirira ntchito mkati mwa thupi. Mkhalidwe wa thupi womwe umabweretsa kusintha kwa khungu sikukhudza khungu lokha - komanso thupi lonse lamkati.
Kutuluka kwa madzi, kukula/kulowa m'mitsempha yamagazi komanso kukhuthala kwa khungu kumatha kuoneka mosavuta mu rosacea, chifukwa kumawonekera pakhungu - pamwamba pa thupi. Mwanjira ina, ndi dalitso kukhala ndi zizindikiro za rosacea, chifukwa zimakuwonetsani kuti pali cholakwika mkati. Kutaya tsitsi kwa amuna ndi chinthu chofanana chifukwa kumasonyeza kusagwira bwino ntchito kwa mahomoni.
Zofooka za Mitochondria
Zonse zomwe zawonedwa ndi kuyeza zokhudzana ndi rosacea zikusonyeza kuti mavuto a mitochondrial ndiye omwe amayambitsa rosacea.
Mitochondria singagwiritse ntchito mpweya bwino ikawonongeka. Kulephera kugwiritsa ntchito mpweya kumawonjezera kuyenda kwa magazi kupita ku minofu.
Mitochondria imapanga lactic acid ikalephera kupeza ndi kugwiritsa ntchito mpweya, zomwe zimapangitsa kuti magazi azituluka nthawi yomweyo komanso kukula kwa ma fibroblast. Ngati vutoli lipitirira nthawi, mitsempha yatsopano yamagazi imayamba kukula.
Zinthu zosiyanasiyana za mahomoni ndi zachilengedwe zingayambitse kusagwira bwino ntchito kwa mitochondrial, koma pankhani ya chithandizo cha kuwala kofiira, mphamvu yofunika kwambiri imachokera ku molekyulu yotchedwa Nitric Oxide.
Chithandizo cha Kuwala Kofiira ndi Rosacea
Chiphunzitso chachikulu chofotokoza zotsatira za kuwala kwa kuwala chimachokera pa molekyulu yotchedwa Nitric Oxide (NO).
Iyi ndi molekyulu yomwe ingakhale ndi zotsatira zosiyanasiyana pa thupi, monga kuletsa kupanga mphamvu, kufalikira/kufalikira kwa mitsempha yamagazi, ndi zina zotero. Chomwe timakonda kwambiri pa chithandizo cha kuwala ndichakuti NO iyi imalumikizana pamalo ofunikira mu unyolo wanu woyendera ma elekitironi a mitochondrial, ndikuletsa kuyenda kwa mphamvu.
Zimalepheretsa magawo omaliza a kupuma, kotero zimakulepheretsani kupeza mphamvu yayikulu (ATP) ndi carbon dioxide iliyonse kuchokera ku shuga/oxygen. Chifukwa chake anthu akakhala ndi kuchuluka kwa kagayidwe kachakudya kochepa akamakalamba kapena akamakumana ndi nthawi yopsinjika/njala, NO iyi nthawi zambiri imakhala ndi chifukwa. N'zomveka mukaganizira za izi, mwachilengedwe kapena pakupulumuka, mumafunika njira yochepetsera kuchuluka kwa kagayidwe kachakudya munthawi yomwe chakudya/ma calories ochepa amapezeka. Sizimveka kwenikweni m'dziko lamakono komwe kuchuluka kwa NO kumatha kukhudzidwa ndi mitundu inayake ya ma amino acid muzakudya, kuipitsidwa kwa mpweya, nkhungu, zinthu zina zakudya, kuwala kochita kupanga, ndi zina zotero. Kusowa kwa carbon dioxide m'thupi lathu kumawonjezeranso kutupa.
Chithandizo cha kuwala chimawonjezera kupanga mphamvu (ATP) ndi carbon dioxide (CO2). CO2 imaletsa ma cytokines ndi ma prostaglandins osiyanasiyana omwe amateteza kutupa. Chifukwa chake chithandizo cha kuwala chimachepetsa kuchuluka kwa kutupa m'thupi/m'dera.
Ponena za rosacea, mfundo yofunika kwambiri ndi yakuti chithandizo cha kuwala chidzachepetsa kutupa ndi kufiira m'derali, komanso kuthetsa vuto la kuchepa kwa mpweya wokwanira (zomwe zinayambitsa kukula kwa mitsempha yamagazi ndi kukula kwa fibroblast).
Chidule
Pali mitundu yosiyanasiyana ya rosacea ndi mawonetseredwe ake
Rosacea ndi chizindikiro cha ukalamba, monga makwinya ndi tsitsi la imvi
Chifukwa chachikulu cha rosacea ndi kuchepa kwa ntchito ya mitochondrial m'maselo.
Chithandizo cha kuwala kofiira chimabwezeretsa mitochondria ndikuchepetsa kutupa, ndikuletsa rosacea